21-HYDROXYALLOPREGNANOLONE
- CAS No.
- 567-02-2
- Chemical Name:
- 21-HYDROXYALLOPREGNANOLONE
- Synonyms
- TDOC;5α-THDOC;ALLO TH DOC;3α,5α-THDOC;5alpha-THDOC;ALLOTETRAHYDRO DOC;ALLOTETRAHYDROCORTEXONE;1-HYDROXYALLOPREGNANOLONE;21-HYDROXYALLOPREGNANOLONE;ALLOTETRAHYDRO SUBSTANCE 'Q'
- CBNumber:
- CB5265066
- Molecular Formula:
- C21H34O3
- Molecular Weight:
- 334.49
- MDL Number:
- MFCD00051144
- MOL File:
- 567-02-2.mol
- MSDS File:
- SDS
21-HYDROXYALLOPREGNANOLONE price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P2016 | 3α,21-Dihydroxy-5α-pregnan-20-one ≥95% | 567-02-2 | 5mg | $116 | 2024-03-01 | Buy |
| Sigma-Aldrich | P2016 | 3α,21-Dihydroxy-5α-pregnan-20-one ≥95% | 567-02-2 | 10mg | $198.8 | 2024-03-01 | Buy |
| Cayman Chemical | 28364 | THDOC | 567-02-2 | 500μg | $41 | 2024-03-01 | Buy |
| Cayman Chemical | 28364 | THDOC | 567-02-2 | 1mg | $78 | 2024-03-01 | Buy |
| Cayman Chemical | 28364 | THDOC | 567-02-2 | 5mg | $263 | 2024-03-01 | Buy |
21-HYDROXYALLOPREGNANOLONE Chemical Properties,Uses,Production
Uses
3α,21-Dihydroxy-5α-pregnan-20-one (THDOC) has been used:
- as an γ-aminobutyric acid type A receptor (γ-GABAA) agonist in voltage-clamp measurements studies in Xenopus oocytes
- to test its effect on the spike-wave discharges (SWD) finasteride-treated rats
- in electrophysiological studies with dentate granule cells (DGCs) post controlled cortical impact (CCI) -induced brain injury
Definition
ChEBI: 5-alpha-THDOC is a 21-hydroxy steroid.
General Description
3α21-Dihydroxy-5α-pregnan-20-one (THDOC) is a neurosteroid. It is synthesized in a two-step process from deoxycorticosterone (DOC) via 5α-dihydrodeoxycorticosterone (DHDOC) intermediate with enzymes 5α-reductase and 3α-hydroxysteroid oxidoreductase catalyzing these steps respectively.
Biochem/physiol Actions
3α,21-Dihydroxy-5α-pregnan-20-one (THDOC) is a positive allosteric modulator of the γ-aminobutyric acid A receptor (GABAA). By modulating GABAA receptor, THDOC allows sustained hyperpolarization and an increase in chloride influx and membrane conductance in neurons. THDOC, thus modulates neuronal excitability. It possesses anxiolytic, anticonvulsant and sedative properties. The levels of THDOC show variation in different physiological states. A low THDOC level in the mensural phase is speculated to play a role in the pathogenesis of catamenial epilepsy (CE) in women. However, elevated levels are reported in depression. THDOC may have an indirect role in the hypothalamic-pituitary–adrenal (HPA) axis activation during acute stress.
storage
Store at RT
21-HYDROXYALLOPREGNANOLONE Preparation Products And Raw materials
Raw materials
Preparation Products
21-HYDROXYALLOPREGNANOLONE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9635 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632 | sales@reading-chemicals.com | China | 15185 | 58 |
| Finetech Industry Limited | 027-87465837 19945049750 | sales@finetechnology-ind.com | China | 9636 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
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